By M. Brizzio
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23163. [Epub ahead of print] Flaumenhaft R, Dilks JR, Rozenvayn N, Monahan-Earley RA, Feng D, Dvorak AM. The actin cytoskeleton differentially regulates platelet alpha-granule and dense-granule secretion. Blood. 2005 May 15;105(10):3879-87. Epub 2005 Jan 25. Fu A, Gu W, Boussert B, Koski K, Gerion D, Manna L, Le Gros M, Larabell CA, Alivisatos AP. Semiconductor quantum rods as single molecule fluorescent biological labels. Nano Lett. 2007 Jan;7(1):179-82. Geys J, Nemmar A, Verbeken E, Smolders E, Ratoi M, Hoylaerts MF, Nemery B, Hoet PH.
Most of occlusive thrombi had a layered structure indicating an episodic growth by repeated mural deposits 13, 14. Morphological studies indicated that plaque complications remained clinically silent days or weeks before the fatal event 15-18. A RMT predisposes patients to recurrent thrombotic vessel occlusion 15, 16, 17, and plaque disruption, fissure or erosion with thrombus contributes to plaque development and progression 18. Therefore, a marker that predicts disrupted, fissured or eroded plaque and the coronary thrombus may have practical clinical applications.
The cardiac isoform has 31 suplementary aminoacids at the N-terminal end of the polypeptide chain and besides it differs from skeletal isoforms as it shows in the tracts of the primary sequences of the protein, a heterogeneity of 69% for the central tract (residues 30 to 110) and 44% for the terminal tract (110-215) which seems to be more stable because of the protection carried out by the subunit C terminal. Troponin T also shows three isoforms codified by genes located in three different chromosomes, one of them is specific for myocardium.
Acute Coronary Syndromes by M. Brizzio
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