By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

ISBN-10: 0309219876

ISBN-13: 9780309219877

Tremendous detrimental ingredients (EHSs)² will be published by accident due to chemical spills, business explosions, fires, or injuries related to railroad autos and vans transporting EHSs. staff and citizens in groups surrounding commercial amenities the place EHSs are synthetic, used, or kept and in groups alongside the nation's railways and highways are in all likelihood vulnerable to being uncovered to airborne EHSs in the course of unintentional releases or intentional releases by way of terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental safety service provider (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality facts in rodents. As a part of its efforts to boost acute publicity guide degrees for EHSs, EPA and the employer for poisonous components and ailment Registry (ATSDR) in 1991 asked that the nationwide study Council (NRC) strengthen instructions for developing such degrees. according to that request, the NRC released guidance for constructing group Emergency publicity degrees for unsafe ingredients in 1993. therefore, typical working systems for constructing Acute publicity guide degrees for harmful components used to be released in 2001, supplying up-to-date approaches, methodologies, and different guidance utilized by the nationwide Advisory Committee (NAC) on Acute publicity instruction degrees for dangerous components and the Committee on Acute publicity guide degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently evaluation the AEGLs built via NAC. in accordance with that request, the NRC prepared inside of its Committee on Toxicology (COT) the Committee on Acute publicity instruction degrees, which ready this document. Acute publicity guide degrees for chosen Airborne chemical compounds is the 10th quantity of the sequence and files for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.

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These single-exposure studies were conducted to assess DMF metabolism, and no adverse effects were reported; thus, the concentration can be considered an acute exposure concentration unlikely to result in adverse effects in healthy adults. Therefore, the intraspecies uncertainty factor is reduced to 3, resulting in a total uncertainty factor of 3. 5 (ten Berge et al. 1986). The value of n was not empirically derived because of inadequate data; therefore, the default value of n = 1 was used for extrapolating from shorter to longer exposure periods, and a value of n = 3 was used to extrapolate from longer to shorter exposure periods.

1984), and 200 ppm (NTP 1992). Indexes of toxicity after repeated DMF exposure ranged from elevated serum enzymes indicative of liver injury to hepatic degeneration and necrosis. From these exposure data, humans would be expected to be less sensitive than laboratory animals (rodents). An intraspecies uncertainty factor of 10 is applied because a host of interindividual differences could affect the manifestation of DMF toxicity: (1) activity of CYP2E1, an enzyme that plays a pivotal role in the metabolism of DMF, to reactive intermediates, can be induced by ethanol consumption, obesity, diabetes, and other lifestyle and genetic factors (Gonzalez 1990; Song et al.

On hospital admission, he experienced upper abdominal pain radiating in his back. Nausea and vomiting, epigastric tenderness, and an erythematous rash on his hands and forearms (possibly suggesting direct skin contact with DMF) developed. /liter (L), but a cholecystogram and intravenous cholangiogram were normal. Following the accident, a search of factory records found that a 28-year-old male coworker had previously been admitted to the hospital following accidental exposure to DMF. Again, the exposure route was not characterized, but this patient too had an erythematous rash on his hands and forearms, and suffered from upper abdominal pain, nausea and vomiting, and epigastric tenderness.

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Acute Exposure Guideline Levels for Selected Airborne Chemicals by National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

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