By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer causing agents covers environmentally and occupationally major cancer causing agents of commercial origins.
The publication discusses the structure-activity relationships, metabolism, and environmental value of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and similar aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental value of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and comparable compounds thiocarbonyl compounds also are encompassed. The ebook additional tackles the structure-activity relationships, metabolism, and environmental value if fatty acids, detergents, and different surfactants with oncogenic strength. The textual content then seems into the impression of chemical reactivity, molecular geometry, and metabolism on carcinogenic task.
Chemists, geneticists, and people desirous about melanoma learn will locate the e-book priceless.
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Extra resources for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
The carcinogenicity of CC14 in the rat has been tested by inhalational, subcutaneous, and oral routes. Costa et al. (235) exposed a group of albino rats to an atmosphere containing CC14 for 7 months. Among the 30 survivors 10 had liver nodules diagnosed histologically as early or established liver carcinomas. The details of the study and the type of control were not given. 3 ml/kg of a 50% solution of CC14 in corn oil. A low incidence of small hepatomas was observed in Buffalo strain rats of both sexes treated at the age of 24 or 52 weeks (236).
In Fischer 344 rats, 1,2-dibromoethane caused significant increases in the incidence of tumors (many malignant) of the nasal cavity (males, 0, 78, 82%; females, 2, 68, 86%), hemangiosarcomas of the circulatory system (males, 0, 2, 30%; females, 0, 0, 10%), adenomas of the pituitary gland (males, 0, 15, 4%; females, 2, 37, 9%) in both sexes; mesotheliomas in the tunica vaginalis (0, 14, 50%) in males; and alveolar/bronchiolar carcinomas or adenomas (0, 0, 11%) and fibroadenomas of the mammary gland (8, 58, 48%) in females.
Similarly, the relative order of potencies (without metabolic activation) is: ds-l,3-dichloro- > mms-l,3-dichloro- > 3-chloro-2-methyl- > 2,3-dichloro- > 3-chloro- > 2-chloro- and 1-chloropropene (inactive), consistent with their relative alkylating activity (72). All the mutagenic halopropenes listed here have allylic structure and are mutagenic as such. The inclusion of an S9 system reduces the mutagenicity of all the halopropenes with the exception of 2,3dichloropropene, which contains a vinylic as well as an allylic structure and the mutagenicity of which can be increased more than 30-fold by metabolic activation (72).
Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms by Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
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