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Additional resources for Amsacrine-Associated Cardiotoxicity
In his ﬁrst clinical paper published in Surgery in 1954,37 Hufnagel reported a series of 23 patients starting September 1952 who had this operation for aortic insufﬁciency. There were four deaths among the ﬁrst 10 patients and two deaths among the next 13. Hufnagel’s caged-ball valve, which used multiple-point ﬁxation rings to secure the apparatus to the aorta, was the only surgical treatment for aortic valvular incompetence until the advent of cardiopulmonary bypass and the development of heart valves that could be sewn into the aortic annulus position.
87 He did not give the date in 1955, but the patient is listed as Human Case 7. Unfortunately, in the same report, cases 1–6 and 8–15 operated on between 1951 and the end of 1955 with various congenital heart defects did not survive the surgery using the pump and monkey lung, nor did another seven children in 1952, all with TGA (see timeline for 1952) using the same bypass technique. Note: This list is not all-inclusive but likely includes most of the historically signiﬁcant clinical open-heart events where a blood pump was used to support the circulation during this period.
The patient died in the operating room. One week later, however, Dr. Gross operated on a second patient, a 12-year-old girl. This patient’s operation was successful. Dr. Gross had been unaware of Dr. Crafoord’s successful surgery several months previously, probably because of World War II. In 1945, Dr. 48 The famous Blalock-Taussig operation also was ﬁrst reported in 1945. 49 At age 8 months, the baby had her ﬁrst cyanotic spell, which occurred after eating. Dr. Helen Taussig, the cardiologist, followed the child for 3 months, and during that time, cyanosis increased, and the child failed to gain weight.
Amsacrine-Associated Cardiotoxicity by dr.salem
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